Pre‐ and postoperative <sup>68</sup> Ga‐DOTATOC positron emission tomography for hormone‐secreting pituitary neuroendocrine tumours
نویسندگان
چکیده
Objectives Somatostatin receptors (SSTRs) are potential targets for detecting pituitary neuroendocrine tumours (PitNETs) that can be visualized effectively with 68Ga-labelled PET tracers. With this study, we have evaluated the diagnostic properties of such a tracer, 68Ga-DOTATOC, in patients hormone-producing PitNETs before and after surgery. Design/Methods This prospective case-control study presents preoperative positron emission tomography (PET) histopathological data 18 somatotroph (n = 8), corticotroph 7) thyrotroph 3) PitNETs. Patients were scanned pre- postoperatively 68Ga-DOTATOC PET. For postoperative part gonadotroph also included. Fifteen healthy controls underwent same protocol once. The maximum standard uptake value (SUVmax) was analysed manually outlined regions around tumour gland controls. specimens collected during surgery subjects assessment adenohypophyseal cell type SSTR expression. Results Thyrotroph showed higher (median SUVmax 41.1; IQR 37.4-60.0) lower (SUVmax 6.8; 2.6-9.3) than normal 13.8; 12.1-15.5). 15.9; 11.6-19.7) similar to gland. There strong correlation between SSTR2 expression (r .75 (P < .01)). In evaluation, able correlate tracer biochemical cure noncure an abnormal magnetic resonance image > 13.8. Conclusions used detect imaging assessment. Corticotroph had significantly compared but without distinct increased clinical is limited.
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ژورنال
عنوان ژورنال: Clinical Endocrinology
سال: 2021
ISSN: ['1365-2265', '0300-0664']
DOI: https://doi.org/10.1111/cen.14425